Pituitary tumour fibroblast-derived cytokines influence tumour aggressiveness
نویسندگان
چکیده
منابع مشابه
Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness.
Stromal fibroblast recruitment to tumours and activation to a cancer-associated fibroblast (CAF) phenotype has been implicated in promoting primary tumour growth and progression to metastatic disease. However, the mechanisms underlying the tumour:fibroblast crosstalk that drive the intertumoural stromal heterogeneity remain poorly understood. Using in vivo models we identify Wnt7a as a key fact...
متن کاملTumour radiobiology beyond fractionation
Historically it has been shown repeatedly that single high doses of radiation do not allow a therapeutic differential between tumor and critical normal tissues but dose fractionation does. The purpose of conventional dose fractionation is to increase dose to the tumor while preserving normal tissue function. Tumors are generally irradiated with 2Gy dose per fraction delivered daily to a more or...
متن کاملPituitary tumour pathogenesis.
Pituitary adenomas are the most common tumours in the central nervous system, make up approximately 10% of all primary intracerebral tumours [1] and are found incidentally in 3-27% of autopsies [2]. The predisposition to tumour formation of the highly specialized cellular phenotypes that characterize the anterior pituitary is unexplained, but it is tempting to speculate that the same hormones, ...
متن کاملPituitary-hypothalamic Tumour Syndromes: Adults
Space Occupying Lesions in the hypothalamic/pituitary region include tumours derived from endocrine or neural tissues, as well as a wide spectrum of more uncommon conditions such us inflammatory processes or metastases. The clinical expression of these lesions depends not only of their nature, but also on the size and position of the lesion, with some common patterns that can lead the clinician...
متن کاملAngioid Streaks in Pituitary Tumour.
IN recent years there have been many references to angioid streaks of the retina found in association with pseudoxanthoma elasticum and Paget's disease of bones (Elwyn, 1953; Cowper, 1954; Bedrossian, 1958; Hogan and Zinmerman, 1962). A review of the current literature on angioid streaks and on brain tumours revealed no cases of angioid streaks in patients who presented with ocular manifestatio...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Endocrine-Related Cancer
سال: 2019
ISSN: 1351-0088,1479-6821
DOI: 10.1530/erc-19-0327